The development has been designed by Assael Architecture and will consist of 137 one to three bedroom homes together with 8,783 square feet of retail space.
The site is currently dominated by the old Empire House office building opposite Turnham Green.
This will be redeveloped into 66 new modern homes with an elegant façade.
Sales of the new apartments are expected to commence in March with construction of the project starting later this year.
Richard Cook, Head of Residential at Lend Lease, said: “The approval of our planning application marks the first key milestone in our aim to significantly enhance this part of Chiswick and is a further example of our commitment to the regeneration of challenging brownfield sites in London.
“It adds to the significant pipeline of homes we are delivering across London, which now totals close to 5,000 across all of our projects.”
Assael Architecture Director, Pete Ladhams, said: “We are delighted that consent has been granted to transform this derelict office building and inactive stretch of Chiswick High Road into an attractive and vibrant new destination.
‘The development will deliver high quality homes and a new public realm that creates a sense of place, improving the character of the conservation area and harnessing local heritage.”