The 279-acre Boots site, which has been home to high street pharmacy and beauty retailer since it was bought by Jesse Boot in 1927, was awarded Enterprise Zone status in 2011.
Boots aims to redevelop part of the site with 82,000sq m of commercial space and 675 new homes as part of a major redevelopment on the area.
This will include the creation of a new highway and bridge across the Beeston Canal to link to the A52.
As part of the first phase, Blackwell will carry out remediation works to ready the site for development and marketing. Initial works are expected to start later this year.
Ken Murphy, Executive Vice President of Walgreens Boots Alliance and President of Global Brands, said: “This contract award is an important step on the development on our site as part of the Nottingham Enterprise Zone.
“Our long term ambition is for the site to be an integral part in the future development, not just of Nottingham, but of the UK, as a leader in health and beauty innovation and excellence.”