The old industrial site will be brought back to life with a mix of homes, commercial office space, retail units and a cinema and boutique brewery.
Carillion is set to start construction on the site next spring.
The contractor will deliver 90,000sq ft of commercial office space, 24,000sq ft of A1 and A3 retail restaurant and bar spaces alongside a mix of 1, 2 and 3 bed apartments and town houses.
Gareth Jackson, development director for Carillion said: “This planning application is the culmination of our work with the HCA, Leeds City Council and local stakeholders to ensure that Tower Works is a fitting and successful addition to the Leeds South Bank regeneration area.
“Carillion’s commitment to Tower Works underlines our belief in the future of Holbeck.
“With iconic buildings, canalside living, great transport links and proximity to the City’s prime civic locations, it’s emerging as Leeds’ most exciting place to live and work.”
Tower Works is being designed by architects Jestico + Whiles and landscape architects Oobe.