Chelsfield, alongside partners Imagination Europe and First Base, are planning more than 3m sq ft of mixed-use space on the docklands site owned by Government.
The scheme will see an iconic flour mill not used since the 1980s converted into a new centre for business and enterprise alongside more than 3,000 homes.
Several branded pavilions will also be built to showcase and exhibit products from leading global brands.
Work began earlier this year, following a £12m government investment secured by the Mayor of London, to demolish parts of the interior of the former flour factory and rid it of asbestos in order to fast track redevelopment.
That work means the site will be ready to welcome the next generation of start-up business by 2017.
Sir Stuart Lipton, who leads The Silvertown Partnership, said: “The decision by the Mayor of London ensures that this derelict and forgotten piece of east London is reinvented as a new creative hub for our capital – drawing the world’s best creative talent, most ambitious start-ups and most innovative businesses – to make, show and share.”
Silvertown Quays is the latest in a string of schemes to regenerate London’s docklands. They include plans to create the UK’s largest floating village at Royal Victoria Dock, the ABP business port at Royal Albert Dock, Siemens Crystal Centre and Crossrail.
Plans are also being developed to build the Silvertown Tunnel to connect the Royal Docks and Greenwich Peninsula, which if approved could become operational by 2023.