It ranks as the most ambitious of several proposed schemes that could turn Manchester city centre into a high-rise residential area.
CQ Investments, part of construction group Renaker Build, is aiming to develop the scheme to provide 1,400 flats on the site between Owen Street and Deansgate.
The four towers will range from 38 storeys to 64 storeys high, overshadowing Manchester’s present tallest building the Beetham Tower, which is 47 storeys high.
Designed by Simpson Haugh & Partners, with Beetham Tower designer Ian Simpson, the glazed towers will feature unusual inverted facades on each face of the buildings.
The scheme has been designed to appeal to both PRS and owner occupiers.
If the plan gets the go-ahead, residents will have access to an indoor tennis court, swimming pool and spa, along with a gym, beauty treatment facilities, cinema and rooftop bar.
Developers are also planning three levels of basement parking, complete with a pick-up and drop-off zone.
A spokesman for CQ Investments said: “Our proposals provide a fantastic opportunity to develop a series of landmark buildings set within a high quality public space creating a new community and attractive destination in the city centre.
“The arrangement, range and specification of accommodation planned combined with the amenity and service provision will deliver highly desirable and important new homes to Manchester.”
The developer said that subject to planning construction work could start as early as this autumn, with completion due in 2020.