The timetable was unveiled as the London Borough of Tower Hamlets granted the green light to plans from a consortium led by Galliard Homes and Lindhill.
The Ailsa Wharf site will contain 785-homes as part of a mixed use regeneration scheme sesigned by architecture practice Stockwool.
Work will transform a heavily contaminated 2.5ha tract of land next to the River Lea which has laid barren and unused for many years.
The approved proposals will create a mixed-use hub of high quality housing and 3,000m2 commercial space in 13 buildings varying between 3 and 17 storeys set within significant areas of new public realm.
The development has the potential to kickstart wider regeneration in Poplar Riverside, particularly the sites to the south such as Iron Mountain and the Nairn Street Estate.
Construction is due to start in 2018 with first completions due in 2021.