Work will start immediately with phase one scheduled to complete in September 2020.
Phase one will see the speculative development of nine industrial and warehouse units totalling 132,000 sq ft and highway improvements including a new roundabout.
One unit totalling 30,000 sq ft has already been pre-let to prestige auto retailer Sytner Group on a long-term lease for pre-delivery inspection and vehicle servicing for clients such as McLaren, Bentley, Rolls Royce and Land Rover.
Caddick Construction North West managing director, Ian Threadgold, said: “We hope this is the start of a successful long-term relationship between our two companies.
“We are enjoying an excellent year of new project wins and look forward to delivering an exceptional business park for Chancerygate.”
At 244,000 sq ft in total, Novus has a gross development value of around £33m.
It is currently Chancerygate’s biggest scheme and once complete will provide high-specification industrial and warehouse space across 16 acres.
Chancerygate development director and head of the company’s Warrington office, Mike Walker, said: “Novus is our flagship development in the North West and working alongside Caddick we start construction with real momentum.
“They have an excellent track record of successfully delivering projects of this type and scale, and we are very pleased to be working with them for the first time.”