The Greenhouse has been used as the site office for Bovis Lend Lease, housing the peak construction 2,000 strong workforce during Phase One of MediaCityUK.
It will now be converted in 32,000 sq ft of rentable office suites for small companies.
Stephen Wild, Managing Director of Real Estate for Peel Media, said: “The Greenhouse will provide self-contained office suites spread over three floors.