New Operator iCITY has agreed a 200-year lease with the London Legacy Development Corporation and will spend £100m adapting the current buildings.
Carillion built the 2012 media centre for £297m.
iCity is vowing to ensure local contractors benefit from supply chain opportunities.
The revamped site will feature three main buildings – a 300,000 sq ft innovation centre, 750 seat auditorium and a 670,000 sq ft building that will house educational space, broadcast studios, office space, and a state-of-the-art data centre.
More than 40% has already been pre-let with tenants including BT Sport and Loughborough University.
iCity expects to take possession of the site early next year when transformation works will begin.
Gavin Poole, CEO of iCITY, said: “We are delighted that iCITY has reached this milestone and that the future of the former Press and Broadcast Centres is secure.
“iCITY is at the heart of the economic and social legacy from London 2012. It will provide much needed infrastructure, commercial space and capacity for the digital and creative industries, the UK’s fastest growing sectors of the economy, as well as much needed studio space in London.
“These buildings present an incredible opportunity to the creative and media sector enjoying unrivalled connectivity and power.”
Mayor of London, Boris Johnson, said: “It’s absolutely fantastic news that the final piece of the Olympic venues jigsaw puzzle has now been firmly put in place.”