The £90m scheme at Langford Lane has been designed by architect UMC to create 430,000 sq ft of research and development space at Kidlington.
It will consist of two Grade A, three-storey buildings with office, R&D and innovation space plus a range of two-storey R&D buildings behind.
Subject to planning consent, work would start on site in early 2015, with a phased completion until 2025.
Angus Bates, CEO of Hill Street Holdings, said: “The submission of our application is an important milestone and follows the site’s allocation in the draft local plan.
“Subject to approval, this scheme will offer much needed, bespoke accommodation for hi-tech, R&D organisations in one of the world’s major research hubs.”
The planning and promotion of the site has been undertaken by Bloombridge.