The £211m contract will deliver Canada Gardens consisting of 743 new Build to Rent homes across seven buildings.
It will be Sisk’s ninth project at Wembley Park in a 12 year history of working with Quintain in transforming the area.
Angus Dodd, Chief Executive of Quintain said: “Sisk has delivered eight successful projects to date at Wembley Park and has been a trusted partner for 12 years.
“I am delighted to continue our partnership with Sisk by awarding them our biggest ever construction contract. All contractors on Quintain’s main framework are valued partners and members of a team working together to bring London property and places to life.”
Stephen Bowcott, CEO of John Sisk & Son said: “At Sisk we are very proud to celebrate another milestone in the important relationship between ourselves and Quintain, who are an immensely valued client for us.
“We have used our previous experience over the last 12 years working with the design teams to drive efficiencies in to the project.
“We always look to add value to the design process with our early input and we will continue to work closely with Quintain as our trusted partner on this latest phase of the development at Wembley Park.
“It is important to us that we maintain the highest standards of project delivery and quality with a health & safety record that makes both organisations proud.”
Sisk is a member of Quintain’s main contractor framework alongside Wates, McAleer & Rushe, McLaren and O’Keefe.
Construction on Canada Gardens is due to complete in 2020.