The first H2 Club will be in Dufours Place, Soho, and includes 230 secure bike parking spaces and 40 showers for cyclists and joggers.
The £1.5m scheme is the first of up to 20 clubs across London planned by developer Reef Estates.
The Soho scheme will also include fitness classes and locker hire to create a generation of ‘H2 Commuters’ who get fit as they travel to work.
Willmott Dixon Interiors will complete the fast-track project by April.
Director Warren Troy said: “This is a completely new concept that we are excited to be involved with from the start.
“The new H2 club will be the first in the world to offer services tailored for the growing number of people who decide to ride, walk or run to work instead of using public transport.”