North Lincolnshire Council approved plans by Able UK for the port-related logistics park on the South Humber Gateway after the developer met several environmental concerns.
The scheme for Able Humber Port is expected to create more than 300 construction jobs when work gets underway.
The port owner plans to build transport depots, warehousing, offices, a business park, motel and energy developments on 770 acres of land at East Halton in North Lincolnshire.
Able UK group development director Neil Etherington said: “We now just have to dot one or two ‘i’s and cross one or two ‘t’s and we will be looking to be on-site in the relatively near future.
“There will be considerable activity over the course of next year.”
It is hoped the superport and new logistics and business park will pave the way for further investment on the South Humber Gateway attracting up to £1.5bn indirect investment.
The site is next to the proposed marine energy park for offshore wind turbine manufacture, also being developed by Able UK, which will submit plans next month.
Richard Kendall, from the Hull and Humber Chamber of Commerce, said: “I think it is good news it has planning permission and hopefully it will get occupied very soon. It will fit into our broader aspirations to become a player in renewables.
“There will be a lot of cross-over between companies on that site and the neighbouring site that will part of the Enterprise Zone.”
The leader of North Lincolnshire Council, Liz Redfern, said: “The site is the fastest growing ports and logistics centre in the country and has the potential to be Europe’s leader in renewable energy.”
A further application for a Marine Energy Park, designed to service the planned offshore windfarms in the North Sea and with the potential to create more then 25,000 jobs, is due to be submitted next month.