The Park will offer up to 8,000 new homes, including 2,800 created in the Olympic Athletes Village.
Andrew Altman, chief executive of the Olympic Park Legacy Company, said: “As one of the most important housing developments in London’s history, these five neighbourhoods will stitch together the surrounding communities of a formerly isolated area through new homes, schools, shops, parks, infrastructure and jobs.”
Chobham Manor, in the north east of the Park, will be the first development.
The neighbourhood is to come complete with 960 homes, a walk-in centre with two GPs and two dentists, two nurseries plus a small shopping area.
The other new residential areas East Wick, Sweetwater, Marshgate Wharf and Pudding Mill will follow in phases.
Amenities including new schools, nurseries, community spaces and health centres, have been positioned to ensure they are accessible to people living around the Park as well as those in it.
Planning applications for the rest of the Park, including the areas around the venues and north and south parkland, will come forward at later dates.
Around 40% of the homes are family homes with the majority of the neighbourhoods drawing inspiration from London’s heritage of terraced housing.
Up to 35% will be affordable housing in line with the London Plan.
They will sit alongside the sporting venues, 6.5 km of waterways, cultural attractions and open spaces, including the Aquatics Centre, Stadium and ArcelorMittal Orbit in the south plaza.
Both of these areas are subject to design competitions currently being run by the Legacy Company with more than 100 teams from Europe, North America and Asia vying to take part.