Chelsfield, alongside partners Imagination Europe and First Base are planning more than 3m sq ft of mixed-use space on the 50-acre docklands site owned by Government.
It won the bid race with plans to build branded pavilions which will showcase and exhibit products from leading global brands.
The development will create about 9,500 permanent jobs once completed as well as providing 2.3 m sq ft of commercial and retail space and around 4,000 homes.
Mayor of London, Boris Johnson, said: “Despite one of the harshest economic climates in decades an urban renaissance is underway in east London and I have no doubt that Silvertown Quays will become a business destination of worldwide appeal.”
Robert Burrow, chief executive of Chelsfield, said: “Chelsfield with our partners Imagination Europe and First Base are delighted to be chosen as preferred developer for The Silvertown. Chelsfield has for many years valued East London as a growth area.”
“We originated Stratford City, which is now a thriving successful mixed used centre. We believe The Silvertown development will be equally successful as it will create a new London destination for technology, medical and brand companies.
“There will be a mixture of sales, education, research and innovation centres which will be surrounded by housing and other uses to make The Silvertown another major East London mixed use project.”