The Spring Mews project is currently out to tender with Bam, Shepherd, Vinci, Sir Robert McAlpine, Ocon and Watkins Jones in the chase for the £50m building job.
CLS also reported today that its other big scheme in the area, known as Vauxhall Square, was progressing well with the local council.
Vacant possession of this second site for 1.5m sq ft is due to be gained from the end of 2014.
The two applications represent a total of almost 2m sq ft of development and a development cost in excess of £450m.
Spring Mews will include 408-bed student accommodation and a 120-bed budget hotel.
Around these CLS aims to build 30,000 sq ft of shopping units and 50,000 sq ft of offices as well as a replacement community centre.
The developer said it was is in active discussions with potential operators and expected to start on site later this year.
Executive Chairman of CLS, Sten Mortstedt, said: “Gaining planning consent at Spring Mews is an important achievement for our plans in Vauxhall, an area of London which we expect will see significant regeneration and growth in the next few years.”