Harrow Council backed the plans to redevelop the 30-acre strip of land in June but needed the go-ahead from Mayor of London Boris Johnson and Home Secretary Theresa May.
The developer plans to build a mix of 985 homes along with industrial units, shops, community facilities and cafes as part of a 10-year development of the site at Harrow View.
Land Securities plans a mix of homes, a community centre, student accommodation, and a retirement home over the next 10-years.
Initially it will spend £10m on local infrastructure under planning s106 agreements.
Kodak is closing down its site as part of a phased consolidation of photographic paper production facilities freeing up land for development in partnership with Land Secs.
The first two phases to be developed would be a 10-acre site that has already been cleared in the south-eastern corner and the 20 adjacent acres occupied by a vacant sports centre, car park and playing fields.
Brian McGowan, site manufacturing manager at Kodak, said: “Kodak has transformed into a successful digital company and as a result of this transition, a number of buildings have been demolished and there will be further consolidation of our site.
“Our arrangement with Land Securities realises the development opportunity presented by land surplus to our requirements.
“We have been, and will continue to be, part of the Harrow community.
“The outline planning application helps to ensure the site continues to play a vitally important role in the future of the borough.”