The male cyclist was pronounced dead at the scene in Ludgate Circus at around 10am.
The truck driver was arrested at the scene but has since been released by the City of London Police on bail with no charges.
The junction has a history of accidents with six cyclists killed or seriously injured between 2008 and 2012.
London Assembly Green Party Darren Johnson claimed that Ludgate Circus featured on Transport for London’s original list of 100 junctions which it planned to overhaul following safety concerns, but that it had not featured on a revised list of 33 junctions where work would be carried out.
Work on Ludgate Circus could begin next year as it lies on the route of the proposed new cycle superhighway in London, presently out to consultation.
Squibb said in a statement: “Further to the fatal accident at Ludgate Circus Junction, on the morning of Wednesday 3rd April, involving a cyclist and a Squibb Group Vehicle, Squibb Group would like to express sincere condolences to the family of the fatally injured cyclist.
“Due to ongoing police investigations Squibb Group are unable to make any further comment at this moment in time but will release a full statement in due course.”