Bristol City Council has granted planning permission for the redesign of the frontage which forms part of a £92m investment to redevelop the hospital.
Specialist contractor D&B Facades will carry out the work to create the design named ‘Veil’, by Spanish architects Nieto Sobejano.
It was one of six submissions put forward for a new facade in an international competition run by University Hospitals Bristol NHS Foundation Trust.
Robert Woolley, Chief Executive Officer at UH Bristol, said: “We are delighted that the new façade design has now been approved by Bristol City Council.
“We believe that Nieto Sobejano’s design strongly meets the original aims of the commission, namely to create a landmark building for Bristol that is welcoming and non-threatening, enhances the streetscape and public realm, and reflects, through excellence in design, our reputation for clinical excellence.
“With the planning permission now in place, we can now move forward with our plans to install the new façade, which is a highly visible aspect of the wider project to refurbish our hospitals.”