The Research and Translation Hub has a development value of £200m and will form the centrepiece of the new Imperial West innovation district in West London.
The 48,000 sq m Hub will deliver world-class education, research and translation activities.
O’Rourke fought-off competition from Balfour Beatty, Kier and Skanska, according to construction information specialist Glenigan, to secure the contract.
Work will start on site next month with group businesses Crown House Technologies, Explore Manufacturing, Expanded, Select Plant and Laing O’Rourke Facades delivering the two buildings by summer 2016.
O’Rourke said its in-house digital engineering expertise, ability to manufacture components offsite and modularise solutions was central to winning the job.
Laing O’Rourke Leader for Construction UK Steve Coleby said: “We are delighted to be working with Voreda and at Imperial College London on a development of such significance for research and business in the UK.
“Laing O’Rourke’s innovative approach to manufacturing and construction techniques along with our direct delivery capability serves as a fantastic complement to the schemes overall vision for being a world-class innovation hub.
“Collaboration, professionalism and attention to detail have been at the heart of the tender process and we now look forward to taking this approach through to the delivery phase.”