BAM Construct UK will build the £8m centre, designed by Maber Architects, for the first intake of students in September 2015.
Derby Manufacturing UTC is a partnership between Derby College, the University of Derby, Rolls-Royce, Bombardier, Toyota Motor Manufacturing, Derby City Council and a wide range of supply chain employers working in local manufacturing and engineering.
It is one of 50 new UTCs being developed across the country which are being developed to fill the skills gap in industry by training young engineers who have the talent and skills that employers need now and in the future.
Derby Manufacturing UTC Principal Designate Philip Morris said: “With planning permission agreed, we are looking forward to seeing the building develop.
“We already have a number of young people who have submitted expressions of interest for joining Derby Manufacturing UTC next September and applications are now being taken and formalised for our first cohort of students in year 10 and year 12.”