The development is the largest standalone housing scheme that Galliford Try has undertaken.
It will see the firm deliver 1,100 mixed tenure homes across 11 individual blocks at the site to the south of the Royal Docks.
The project will be delivered through an existing joint venture with Thames Valley Housing Association with a third of the homes built for market rent.
Galliford Try’s Linden Homes, Partnerships and Infrastructure businesses will all be involved in the project.
The 5.9 acres hectares development site is bounded by Silvertown Way to the east and the railway line to the west with the northern boundary connecting to the A13 and Canning Town underground station.
It will consist of homes for sale, rent and shared ownership, a hotel, restaurant, employment and commercial space.
Also, Galliford Try has been appointed as preferred developer for a further 210-home regeneration scheme in the Bristol region by the Homes and Communities Agency’s Delivery Partner Panel.
This scheme is anticipated to have a gross development value of approximately £40m.
Galliford Try Chief Executive Greg Fitzgerald said: “We are delighted to have been selected for both these schemes which underline our strong relationship with the GLA and HCA.
“These schemes are testament to the combined resources of the group and our proven expertise in regeneration and affordable housing projects.
“It underlines our continued investment in delivering much needed homes and working in long-term partnerships with our partners in the sector.”