The firm took over from developer Doric after its £100m plans were rejected by the Vale of White Horse District Council in 2014.
Following an eight-month consultation Mace has set out plans to build 149 new homes, a 122-bed hotel and 262 rooms for students accommodation.
The plans are based on new retail space for smaller shops rather than major new store developments. As part of Mace’s new application, an agreement has been made with the Co-operative supermarket to keep it as part of the new centre.
In total over 14,000 sq ft of shops, restaurants and cafes also included in the plans.
Huw Griffiths, development director at Mace said: “We are pleased to submit an application for the redevelopment of the West Way area, excluding Elms Parade, Field House and the vicarage of St Peter and St Paul Church.”
“We are pleased that feedback from the public exhibition in December showed that a clear majority of residents welcomed how we had changed the scheme through consultation.
“In addition we can today confirm that we have agreed terms for Co-Op to come back into the redeveloped West Way. Co-Op have traded in Botley for over twenty years and, if our application is consented, will trade from a slightly larger and more modern store than their current facility, anchoring the new West Way.”