Developers Stanhope and Mitsui Fudosan plan to build three office blocks at White City Place on the 17-acre vacant, adjacent to the Imperial College campus.
The landmark office complex plan marks the third phase of development at White City and include a major stepped block known as Gateway East rising to 21 storeys.
It will be accompanies by second big block rising to 11 storeys, accompanied a the third smaller building three floors tall.
Contractor Lendlease has drawn up the construction plan for the developers with construction expected to start on site in November next year.
Architect Allies and Morrison designed the project, with AKTII on board as structural engineer and Sweco acting as services engineer.
The Gateway development will complete White City Place, which will total over 2 m sq ft.