Designed by architect Pollard Thomas Edwards, work is now expected to start on site this summer.
A site energy centre will be built for district heating that retains the iconic Kodak chimney.
Future phases will deliver a total of 1,150 new homes, 350,000 sq ft of office, senior living facilities, a community centre and leisure uses.
Matt Calladine, Regional Land & Development Director at Barratt London said: “We are delighted to have secured reserved matters consent for the first phase of Harrow View East.
Tom Shaw, Operations Director (Development) at the Hyde Group said: “The Harrow View East site is a prime example of how partnerships, between organisations like Barratt London and Hyde, can deliver many of the new homes that the people of Harrow and London so desperately need.”