The family-owned firm based in Tameside secured the £17m contract to provide the eight-storey aparthotel located on Mason Street, New Cross.
The scheme will contain 224 rooms via 48 one-bed and 176 studio apartments with reception, cafe and gym.
Work has just started on site with completion due in December 2019.
This represents the third Staycity aparthotel in Manchester alongside its other properties at Laystall Street and Manchester Piccadilly.
The client project team includes architect SimpsonHaugh, structural engineer SHED, mechanical and electrical engineer JH Partners and employer’s agent/quantity surveyor, AFA.
Bardsley is already providing a 172-room hotel with gym, café, restaurant, conference and meeting facilities for AC Hotels by Marriot, part of Marriott International, on a neighbouring site bounded by Mason Street and Cable Street, via a £15.5m contract with Axcel Hospitality.
Ged Rooney, procurement director at Bardsley Construction, said: “Bardsley is an increasingly active player in the delivery of high quality hotel accommodation in Manchester where demand for new hospitality space continues to rise as the city improves its international connections with a truly global visitor market.”