Lock picked-up the accolade for his work on the demanding V&A Museum site in South Kensington, London.
He beat 63 finalists to the trophy for his work on the museum’s new gallery, courtyard and entrance.
The work was completed in March 2017, in 166 weeks on a contract with a final value of £38m.
CIOB President Chris Soffe said: “The CIOB’s Construction Manager of the Year Award is a significant one.
“We know that those in construction often stay in the sector for the duration of their career and acknowledging those at the peak of their profession is important.
“The skills of all the medal winners have been tested to the limit and I congratulate all of them.
“But this years’ winner has achieved something truly remarkable. A challenging, high-profile project, pulled off with skill, expertise and great leadership is rightly being recognised.
“It’s an inspiration and a great example of why people come into our industry – how many people will look at a unique building like the V & A and be able to say ‘I helped build that’.”
CIOB Chief Executive Chris Blythe said: “CMYA has always been a unique barometer for management, and leadership, talent in our sector and in our 40th year it’s been no exception.
“We’ve had professionals working on projects of all shapes and sizes challenging for a place as a medal winner.
“Competition was fierce but Neil stood out for the judges with an outstanding combination of technical expertise, professionalism and brilliant communication skills.”
For a full list of winners click here