The scheme, designed by architect Studio Egret West, comprises six buildings, offering 424 homes, for sale and rent, along with 100,000 sq ft of office space and 37,000 sq ft of retail, leisure and workspace.
The site is adjacent to Maidenhead station, where Elizabeth Line trains will arrive next year, and is a key town centre regeneration opportunity.
HUB will be looking to start on site in early 2019 and will soon be going to market for a contractor.
Extensive demolition of existing buildings at the site will now get underway.
Steve Sanham, Managing Director at HUB, said: “This is a fantastic decision for Maidenhead. The Landing site has been subject to far too many false starts and delays.
“We are confident our scheme will bring a buzz back to the town centre and revitalise it in the way the people of Maidenhead have told us they want. We now look forward to getting on and delivering it.”