Plans include 350 new homes alongside commercial and community development within a parkland setting.
A further part of the flagship site is subject to a draft allocation for development, which if adopted could provide up to 250 more homes and 200,000 sq ft of commercial space.
Wilton Park is close to Junction 2 of the M40 and to Beaconsfield and Seer Green Stations, providing access to London Marylebone within 23 minutes.
Stephen Wicks, CEO of Inland Homes, said: “After a number of years of hard work on Wilton Park, I am delighted with the positive decision delivered by the planning committee yesterday.”