Harvey UK will carry out all of the painting, decorating, hygienic coatings and specialist flooring in the 185-bed Cleveland Clinic London in Grosvenor Place, Belgravia.
The development is being carried out by contractors Sir Robert McAlpine.
The eight-storey 324,000 sq ft hospital is the first European venture for the Ohio-based Cleveland Clinic which has 16 hospitals in the United States as well as facilities in Canada and the United Arab Emirates.
Harvey UK managing director Tony Harvey said: “This hospital will be among the most technologically advanced in Europe and is set to be a leader in medical treatment and research.
“Our work involves specialist flooring and finishes and will draw on our experience in other large hospitals, including the Queen Elizabeth Hospital in Birmingham which we have been supplying finishing services to for the last 10 years.”
Harvey UK has also carried out work at Great Ormond Street Hospital in London and the Royal Papworth Hospital in Cambridge.