The single job catapulted the firm to the top of the October rankings for work won, recharging its orders secured this year.

The Los Angeles-based cancer research institute plans to establish a UK base and build the big campus at the established Oxford Science Park to the south east of city.

According to data compiled by Barbour ABI, the total value of awards secured by the 50 most successful contractors totalled £3.29bn, around £700m up on September’s below average total. This represented 128 projects in number.

In the rolling 12-month league of wins, Bouygues took top ranking, now closely chased by Morgan Sindall with Balfour Beatty in third place.

Network Rail’s £140m masterplan to deliver extra train capacity at Darlington station

Among the other big wins Willmott Dixon came second in the month with several new orders including vamping Darlington Station and a new college building for Wigan and Leigh College’s Parson’s Walk campus.

Telehouse South Docklands building will be refurbished with roof-top plant also replaced

In London Skanska picked up a £158m datacentre refit for provider Telehouse at Docklands in London.

The riverside job will be one of the largest fit-outs, in terms of financial value, that Skanska UK has undertaken.

New blocks of flats follow earlier leisure centre and school projects delivered by Morgan Sindall

London’s Hackney Council has appointed Ardmore to deliver the final phase of its Britannia residential-led regeneration scheme next to Shoreditch Park.

The £154m design and build contract will see Ardmore deliver 371 mixed-tenure units within four residential buildings of up to 25 storeys.

Echo Street project will deliver over 1,200 rooms next to Vimto Park in the Whitworth Street Conservation zone

In Manchester, Bowmer & Kirkland will build a £130m triple tower scheme at Echo Street for student accommodation provider iQ Student Accommodation.