Plans will see Taylor Wimpey develop 290 new homes at Battersea Park East in Nine Elms.
The house builder will also finance the redevelopment of St Mary’s Primary School and contribute £7.8m towards improving transport infrastructure and local community services.
The 4.5acre site is currently home to a series of commercial and light industrial buildings and the existing primary school which is sliced into sections by two Victorian railway viaducts.
The approved scheme would reconnect the site with a network of pedestrian and cycle routes, including four links through the viaduct arches.
A series of new buildings ranging in height from one to 18 storeys would be created as well as a new public square. In total there would be 5,440 square metres of public space.
A new pedestrian link between Queenstown Road and Battersea Park Stations will run through the site from north to south. A second entrance to Queenstown Road Station would also be created.
At ground floor level the development would be brought to life with shops, cafes, bars and galleries – many of which would be provided in a series of newly refurbished railway arches.
The new St Mary’s will include a 60 place nursery and capacity in the main primary school will increase to 420 pupils.
Planning applications committee chairman Sarah McDermott said: “This project will stitch together a badly disjointed corner of Battersea.
“The new routes through the railway viaducts will be of great value to communities on all sides and commuters will benefit from the connection between Battersea Park and Queenstown Road stations.
“The new public spaces are very welcome and the refurbished railway arches are an exciting feature. Local people will look forward to seeing so many of these interesting spaces brought back to life and we will work with Network Rail and the developer to attract a lively mix of uses.
“A fully redeveloped primary school, 60 affordable homes and a £7.8m contribution to improving infrastructure completes an impressive package of benefits for Wandsworth residents.”