Plans include building two hotels with 150 and 180 beds and a 45,000 sq ft office building.
There will also be 206 residential units, a third of which are planned to be affordable housing.
The site formerly occupied by the industrial equipment manufacturer Alfa Laval has laid derelict for 20 years.
The old Alfa tower on the site will be retained under plans drawn up by Assael Architecture.
Assael Architecture managing director John Assael said: “Having secured consent, a strategic and derelict site can be brought back into use and the challenging transformation of this pivotal part of Brentford can finally get underway.”