Wates has signed a deal worth £200m over 10-years covering repair works in the Bermondsey and Rotherhithe areas of the south London Borough.
Rival refurb specialist Apollo has nabbed the Peckham and Camberwell region in a deal worth an estimated £150m over the period.
The third deal worth £120m goes to Essex-based Breyer covering works in the Bankside and Walworth areas of the borough.
London refurbishment specialist A&E Elkins took the fourth smaller geographical lot for Dulwich, Nunhead and Peckham Rye worth £30m.
Work to be carried out by the contractors covers a full spectrum of external and internal housing maintenance from roof renewals and structural and concrete repairs to window replacement and landscaping.
Saltash Construction was named the successful bidder to work on major voids and street properties across Southwark under a separate £30m deal.