The Radclyffe Park proposal includes plans for 114 homes, 14 shops, a 50,000 sq ft Morrisons and a Travelodge hotel.
Construction of the new Morrisons is due to start next month, followed by Travelodge in January 2011.
The development is the latest milestone in the regeneration of Ordsall, led by the £150m of private investment by LPC Living over the past five years.