The win is due to be confirmed this week by Manchester Airports Group.
The team faced intense competition from a number of rival consortia including Kier Property.
The win would be a major boost for Carillion’s construction arm.
The company has been following a strategy of reducing construction turnover in recent years which saw its profits jump 25% at the division in the latest results.
But Carillion is starting to reappear on major bid lists again and is also in the running for the £350m first phase at Battersea Power Station.
Manchester Airport Group has planning permission for 1m sq ft of offices, 382,639 sq ft of advanced manufacturing, 2,400 new hotel beds, and 1.4m sq ft of logistics space at the site.
A MAG property spokesman told the Manchester Evening News: “No party has yet been selected for the final stage in our joint venture partner selection process.
“We are pleased with the level of interest shown to date by a number of parties in relation to the Airport City Project at Manchester Airport; as a number of bids have come from a range of international developers and funders.”