The scheme brings Lend Lease’s tally of planned homes with approval in Central London to more than 700 so far this year.
Cobalt Place on Surrey Lane will comprise 104 homes and will be arranged across two buildings of five and six storeys respectively.
The second development, Victoria Drive, will provide 110 new homes comprising 55 houses and 55 apartments.
Richard Cook, Lend Lease’s head of residential, said: “Our aim is to become one of the leading residential developers in the capital and we shall be looking to partner with landowners in both the public and private sectors to bring forward more new homes for Londoners in the next few years.”
In addition to the new homes, Lend Lease will also build new school facilities for the local Saint John Bosco College, as well as community facilities.
Lend Lease began work on its other major residential site in Central London, Elephant & Castle, earlier this year.
The £1.5bn regeneration will deliver 3,000 news homes and more than 100,000 sq ft of retail and leisure space over the next 10 years.
Construction has started on One The Elephant, a landmark 37-storey tower featuring 284 new homes, and Trafalgar Place, a development on the site of the former Heygate Estate which will house 235 units.