The hub will open in the environmentally-friendly Blue Planet warehouse built by McLaren Construction on the Chatterley Valley site.
JCB has agreed a long-term lease for the building and has also signed an option to purchase an adjacent 7.7 acres of land for future expansion.
The deal has been part-financed through the Government’s Regional Growth Fund.
The distribution hub will be commissioned this month and by the end of the year will employ around 60 people.
JCB CEO Alan Blake: “Staffordshire is where JCB’s business started nearly 68 years ago and I’m delighted that our latest expansion is creating jobs in the county which has been our home for so long.
“Staffordshire is a fantastic place to do business and this site offers some huge advantages for JCB, particularly with transport links to the A500 and M6.”